Objective To provide scientific evidence for disease prevention and control， the epidemiological characteristics of foodborne disease in Hangzhou City were studied.Methods Data on foodborne diseases in 60 surveillance hospitals in Hangzhou were collected from 2012 to 2020. Epidemiological and pathogenic characteristics of these surveillance data were analyzed.Results A total of 54 479 cases of foodborne disease were reported in Hangzhou from 2012 to 2020， and most cases （67.83%，36 954/54 479） appeared from May to October. Adults 26 to 35 years old （21.78%，11 865/54 479） and children ≤5 years old （17.08%，9 307/54 479） were more vulnerable to foodborne disease. Among different occupational groups， the proportion of farmers was the highest， followed by official staff and nursery children. A total of 41 905 samples were collected， and 3 380 strains of pathogens were isolated. The positive rate of Norovirus was the highest （8.77%，734/8 370）， followed by Vibrio parahaemolyticus （2.68%，1 097/40 914）， Diarrheogenic Escherichia.coli （2.39%，527/22 012）， Salmonella （2.38%，978/41 052）， and Shigella （0.11%，44/41 046）. The Norovirus positive rate peak was observed in March and November， whereas that of Vibrio parahaemolyticus was in August.Conclusion The incidence of foodborne diseases in Hangzhou City has noticeable seasonal and population distribution characteristics. The monitoring of foodborne pathogens and the suspicious food investigation of foodborne disease cases should be strengthened to provide technical support for effective prevention and control.