Objective To understand the residues of tetracycline antibiotics （TCs） in drinking water in He’nan Province， and conduct health risk assessment.Methods Tap water samples were collected from He’nan Province， and the residues of TCs in the water samples were examined by solid phase extraction and high performance liquid chromatography. A risk calculation model was used to assess the health risks， and the total carcinogenic and non-carcinogenic risks of various antibiotics were obtained by simply adding up the carcinogenic and non-carcinogenic risks of each contaminant separately， without considering the effects of contaminant interactions.Results Differential hygromycin and chlortetracycline were not detected in any of the different water source types， while the remaining nine TCs were detected， with detection rates ranging from 6.0% to 100.0% and concentrations ranging from ND to 3.23 ng/L.Oxytetracycline and chlortetracycline were not detected in different water sources； Doxycycline and Chlortetracycline are detected in source water， factory water and terminal water， while Demeclocycline and methylenenenenebc oxytetracycline are only detected in the reservoir and groundwater in factory water， but are detected in other water sources； Tetracycline and Oxytetracycline were not detected only in the reservoir water of source water， factory water and terminal water， but were detected in other water sources. Minocycline was detected only in the river water of source water and terminal water； Chlortetracycline， doxycycline and methylenenenenebb oxytetracycline were detected during the normal water period in Henan Province， and the main pollutants were doxycycline； However， in the dry season， it was found that epidoxycycline， tetracycline， doxycycline， Oxytetracycline， Minocycline， methylene Oxytetracycline， and chlorotetracycline were the main pollutants of epidoxycycline， Oxytetracycline， and Oxytetracycline； The concentration of TCs in source water of He’nan Province ranges from ND to 3.21 ng/L， factory water ND to 1.66 ng/L， and peripheral water ND to 1.16 ng/L； Non carcinogenic risk of TCs in drinking water sources， factory and peripheral water samples during dry and normal water periods 3.40×10^-7-3.28×10^-6， far less than 1； the total carcinogenic risk was 1.30×10^-7-1.43×10^-6， much less than 10^-4， within the acceptable range， and the health risk of drinking water is higher in adults than in children.Conclusion There is a problem of TCs pollution in drinking water in He’nan Province. The main pollutants are doxycycline， epidoxycycline and Oxytetracycline， and the health risk is at an acceptable level.