Objective The disease burden of foodborne acute gastroenteritis caused by non-typhoid Salmonella in Heilongjiang Province was estimated to provide evidence for managing and surveilling foodborne diseases.Methods The visit rate for acute gastroenteritis was obtained through a disease burden survey of acute gastroenteritis cases in Heilongjiang Province. The sampling rate， detection rate， and reported cases of non-typhoid Salmonella were obtained from the foodborne disease surveillance data system for Heilongjiang Province. Using the above two datasets， a pyramid model was constructed to estimate the number and incidence of acute gastroenteritis caused by non-typhoid Salmonella in Heilongjiang Province. @Risk8.2 software was used for the probability estimation and uncertainty analysis of the incidence data for non-typhoid Salmonella-related acute gastroenteritis. The foodborne non-typhoid Salmonella acute gastroenteritis incidence was further estimated.Results An estimated 76 224 cases of acute gastroenteritis caused by non-typhoid Salmonella were reported in Heilongjiang Province （95 % CI： 60 203-96 626）， and the annual incidence was 202.0/100 000 （95 % CI： 159.6/100 000-256.1/100 000）.Conclusion Non-typhoid Salmonella has caused a large burden of foodborne diseases in Heilongjiang Province， especially in the elderly and infants.