Objective To investigate the contamination status of foodborne pathogens in meat products in He’nan Province and analyze the serotyping and drug resistance characteristics of Enterobacteriaceae.Methods A total of 1 934 samples of meat products were collected from 21 surveillance sites， including Zhengzhou City， He’nan Province， from 2017 to 2021. Seven foodborne pathogens， including Salmonella， Diarrheogenic Escherichia coli （DEC）， Yersinia enterocolitica， Clostridium perfringens， Listeria monocytogenes， Staphylococcus aureus， and Campylobacter jejuni were detected according to the National Food Contamination and Hazardous Factors Risk Monitoring Manual and the He’nan Food Safety Risk Monitoring Program. The drug susceptibility of DEC and Salmonella was tested using the broth microdilution method to analyze the drug resistance rate， spectrum， and other features.Results Four hundred and seventy eight strains of pathogenic bacteria were detected in 1 934 samples， including 96 strains of Salmonella of 26 serotypes， mainly Salmonella enteritidis； 82 strains of DEC， with a predominant pathotype of Enteroaggregative Escherichia coli （EAEC）； 68 strains of Clostridium perfringens； 38 strains of Yersinia enterocolitica； 33 strains of Campylobacter jejuni； 140 strains of Listeria monocytogenes； and 21 strains of Staphylococcus aureus. The total detection rate of pathogenic bacteria was 24.72%； for prepared meat products， it was 89.00%， followed by raw poultry meat at 36.79% and raw livestock meat at 22.35%. The highest antibiotic resistance rates of the 96 strains of Salmonella were for ampicillin （71.88%）， nalidixic acid （63.54%）， and tetracycline （58.33%）. Eighty-two DEC strains were resistant to tetracycline （84.38%）， ampicillin （67.19%）， and chloramphenicol （64.06%）， with widespread multiple drug resistance.Conclusion The meat products of He’nan Province were contaminated by pathogenic bacteria to varying degrees， especially in prepared meat products. The most common Enterobacteriaceae were DEC and Salmonella， which were mostly resistant to ampicillin and showed multiple drug resistance. The supervision and management of meat products should be strengthened to reduce the incidence rate of foodborne diseases and ensure public food safety.