Objective To summarize the characteristics of foodborne diseases in Guangdong Province in 2020， and to provide scientific basis for prevention and control strategies.Methods The data from January 2020 to December 2020 in the National Foodborne Surveillance Reporting System （CFSA） were with descriptive epidemiological analysis， conducted according to the three distribution and pathogenic factors of the disease. SPSS 21.0 software was used for statistical analysis.Results In 2020， a total of 27 397 cases of foodborne diseases were reported， with an average annual incidence of 0.24‰ （27 397/115 210 000）， a hospitalization rate of 10.66%（2 920/27 397）， and no deaths. The incidence in the Pearl River Delta region was 0.28‰ （18 303/6 447 million）. The hospitalization rate was 6.88% （1 259/18 303）， and the incidence rate in eastern and northwestern Guangdong was 0.18‰ （9 094/5 074 million）， and the hospitalization rate was 18.26% （1 661/9 094）. The main symptoms of the cases were diarrhea， and the ratio of male to female was close to 1∶1. The number of cases in each age group was 31.51% （8 633/27 397） in the 31-59 age group. Among the occupational population， children living in the diaspora accounted for 16.86% （4 620/27 397）， while students accounted for 16.48% （4 515/27 397）. The peak of reported cases was from August to December. The main food exposed cases were mixed food 7 392 cases （27.08%， 7 392/27 297）， meat and meat products 4 511 cases （16.53%， 4 511/27 297）， grain and its products 3 734 cases （13.68%，3 734/27 297）； The main feeding places were 65.53%（17 954/27 397） at home and 15.03%（4 117/27 397） at restaurants. Among 4 395 cases， 1 171 were positive for pathogenic bacteria， and the overall positive rate of pathogenic bacteria was 26.64% （1 171/4 395）. The positive rate of Salmonella was 26.23% （1 153/4 395）. Sixteen strains of Vibrio parahaemolyticus were positive， and the positive detection rate was 0.36% （16/4 395）. Two strains of Escherichia coli were positive， and the positive detection rate was 0.05% （2/4 395）. The positive rate of Shigella was 0.02% （1/4 395）. The positive detection rate was the highest in July， and the main exposed food was grain and its products. Eleven cases were positive for norovirus and the overall positive rate was 0.25% （11/4 395）. The positive rate of norovirus was the highest in January， and the main exposed food was meat and meat products.Conclusion The foodborne disease incidence of Guangdong Province in 2020 is low but the hospitalization rates have certain proportion， western part of guangdong region has low incidence but the hospitalization rate is higher， the pearl river delta region high incidence but hospitalization rate is low， cases analysis showed that family scattered children and students accounted for the high proportion of the crowd， the cases were mainly in the summer， Salmonella detection rate is higher， it should strengthen the focus on the prevention and control of the crowd.