Objective To investigate the contamination of Salmonella in retail chickens in Ji’nan city from 2020 to 2021， and to explore the prevalence of the mobile colistin resistance gene （mcr） among these Salmonella isolates.Methods From December 2020 to November 2021， 260 retail chicken samples were collected in Ji’nan City， and Salmonella was isolated and confirmed according to GB 4789.4—2016 “National food standard - Food microbiological examination： Salmonella”. Serotype identification and mcr gene screening were performed for all Salmonella isolates by polymerase chain reaction （PCR）. The drug resistance of mcr gene-positive strains was tested by micro-broth dilution method.Results A total of 61 in 260 retail chicken samples were positive for Salmonella detection with the contamination rate of 23.46% （61/260）. The highest contamination rate was 53.33% （32/60） for samples collected in autumn. One hundred and three Salmonella strains were isolated， 56 of which were Salmonella Enteritidis， accounting for 54.37% （56/103）. Two Salmonella Indiana， isolated from two separate chicken wing samples collected from different regions， were positive for mcr-1 gene， with a positive rate of 1.94% （2/103）. Antimicrobial susceptibility testing revealed that both of the two mcr-1-harboring Salmonella Indiana were multi-drug resistant， and one of them was concurrently resistant to all 12 categories of tested drugs， including carbapenems and polymyxins.Conclusion There was a certain degree of Salmonella contamination in retail chickens in Jinan from 2020 to 2021， and the contamination rate of the samples collected in autumn was higher than in any other seasons. Salmonella Enteritidis was the predominant serotype. It should be of concern that a Salmonella isolate carried mcr-1 gene with severe multidrug resistance to both colistin and carbapenems， indicating that the surveillance for Salmonella in the whole chain of chicken production should be strengthened continuously， to provide important basic data for the prevention and control of foodborne diseases.