Objective To evaluate the reproductive toxicity of water extract of flower of Dendrobium devonianum Paxt.Methods According to the reproductive toxicity evaluation from National Standard of the People’s Republic of China ‘Reproductive Toxicity Study’（GB 15193.15—2015）， 240 nine-week-old SD rats （120 male and 120 female） were randomly grouped by body weight at a dose of 0.0， 2.5， 5.0 and 15.0 g/kg?BW， respectively. SD rats were administrated by gavage. The detection included the body weight and and ingestion variations from 1^st to10^th week， reproductive organ weights and coefficients of F0 rats； the sperm parameters of F0 male rats， and estrous cycles， fertility index （conception and pregnancy rate）， teratogenicity index （uterus weight， implantation number， corpus luteum number， living embryo number， resorption embryo number/rate and dead embryo number/rate） of F0 female rats； the survival rate and body weight variation during lactation period， anogenital distance， average litter size， sex ratio of F1 rats； the puberty onset （testis descending， foreskin separation， vaginal opening）， body weight variation， reproductive organ weights and coefficients， and sperm parameters of F1 rats； the pathological examination on harvested organs of F0 and F1 rats including testis， epididymis， uterus and ovaries.Results Compared with control group， no significant difference in reproductive toxicity to F0 and F1 rats was observed in three dose groups （P>0.05）. And no significant change was observed via histopathological examination.Conclusion In this reproductive test， the no observed adverse effect level （NOAEL） of water extract of the flower of Dendrobium devonianum Paxt.is 15.0 g/kg?BW.