Objective To provide data for prevention and control of foodborne diseases caused by Vibrio parahaemolyticus from salmon， the serotype， virulence gene and drug resistance of Vibrio parahaemolyticus from salmon in Guangzhou in 2019 were studied.Methods The isolation， quantification and serotype of Vibrio parahaemolyticus in 90 salmon samples were detected based on GB 4789.7—2013. Identification and drug resistance were carried out by automatic microbial identification system， and the virulence genes were detected by PCR amplification.Results Vibrio parahaemolyticus was detected in 16 samples of 90 salmons （17.78%）. The contamination level of positive samples ranged from 3.6 to 93 MPN/g， of which the highest detection rate was found in wholesale market （27.50%）. Seventy two strains which were isolated from positive MPN counting tubes were serotyped into 11 groups by serum agglutination test， the total typing-rate was 80.56%. The isolates were concentrated on serum group O11， O9 and O6 serotypes， accounting for 51.39%. Seventy two isolates carried tlh gene， while tdh and trh gene were not detected. The antibiotic sensitivity analysis revealed that all of the isolates were sensitive to 5 types and 18 kinds of antibiotics such as carbapenems， monobactams， aminoglycosides， quinolones and nitrofurans， 97.22% of the isolates were resistant to ampicillin. A few isolates were resistant to piperacillin （1.39%） and co-trimoxazole （5.56%）， 6.94% of the isolates were resistant to 2 antibiotics， and none of the isolates showed multi-drug resistance.Conclusion The salmons from Guangzhou market were highly contaminated by Vibrio parahaemolyticus， and the serotypes of isolates were diverse. The isolates were nonpathogenic， and they were drug resistance to some extent， which indicated potential risks to human health.