Objective A fast confirmation method was developed for the determination of five nitroimidazoles drug residues in animal-derived foods by ultraperformance liquid chromatography-triple quadrupole/linear ion trap mass spectrometry coupled with solid phase extraction.Methods The samples were extracted with 1% formic acid-acetonitrile and then centrifuged. The supernatant was directly purified by solid phase extraction based on PRIME HLB cartridge， and then determined by ultraperformance liquid chromatography-triple quadrupole/linear ion trap mass spectrometry. The purification condition， mobile phase and chromatographic column were optimized. Under the optimal conditions， the sample was purified by prime HLB column and analyzed by BEH C₁₈ column with 0.1% formic acid- water and acetonitrile as mobile phase. The five nitroimidazoles were detected with positive electrospray ionization tandem mass spectrometry in the multiple reaction monitoring-information-dependent acquisition-enhanced product ion （MRM-IDA-EPI） mode， and quantified by isotopically labeled internal standard.Results The limits of quantitation were from 0.30 to 0.80 μg/kg. The average recovery rates of the 5 nitroimidazoles were 73.2%-115.2% with relative standard deviations of 3.2%-9.3% （n=6）.Conclusion The developed method is rapid， sensitive， accurate and suitable for the detection of nitroimidazole residues in animal-derived foods. The method can be used for screening and confirmation of samples in large quantities.