Objective To provide a basis for formulating applicable prevention and control strategies for toadstool poisoning， the epidemiological characteristics of toadstool poisoning events in Enshi Tujia & Miao Autonomous Prefecture（Enshi）， Hubei Province from 2015 to 2021 was analyzed.Methods The descriptive analysis was conducted on poisoning incidents reported by Hubei Food Safety Standards， Monitoring and Evaluation Platform.Results From 2015 to 2021， a total of 558 cases and 804 patients of toadstool poisoning were reported in Enshi. The main cause of toadstool poisoning was accidental taking and eating. There were 45 foodborne outbreaks caused by toadstool poisoning， with 152 cases and 7 deaths， and the fatality rate was 4.61%. From the second quarter to the fourth quarter， toadstool poisoning occurred frequently in rural households. The prevention and control strategies mainly included monitoring， publicity， risk analysis and assessment， timely treatment and other common measures.Conclusion According to the retrospective analysis results of poisoning poisoning events in Enshi from 2015 to 2021， it is needed to establish effective risk warning system and strengthen the publicity and education to prevent or reduce the occurrence of poisoning according to the key seasons， regions， places and population.