Objective To analyze the epidemiological characteristics of mushroom poisoning events in Guangxi， and provide scientific evidence for the control and prevention strategy.Methods The descriptive analysis was conducted on the incidence data of mushroom poisoning events in Guangxi reported through the Foodborne Disease Outbreak Reporting System from 2015 to 2020.Results A total of 189 mushroom poisoning events were reported with 789 poisoning cases and 10 deaths in Guangxi from 2015 to 2020. The case fatality was 1.27%. The highest number of food poisoning incidents was found in 2020， accounting for 38.10%（72/189） of the total. The majority of the mushroom poisoning events occurred from May to September. Guilin， Baise， Wuzhou and Qinzhou were areas of high incidence of mushroom poisoning events. Family was the main places for mushroom poisoning events， accounting for 93.65%（177/189）of the total.Conclusion The prevention and control strategies of mushroom poisoning in Guangxi should be formulated according to the characteristics of high-incidence seasons， high-incidence areas and high-risk populations， and the publicity and education of families in rural areas should be strengthened to improve the public awareness of prevention.