Objective To estimate the global prevalence and concentration of deoxynivalenol （DON）， aflatoxins （AFs）， zearalenone （ZEN）， nivalenol （NIV）， T-2 toxin （T2）， HT-2 toxin （HT2）， ochratoxin A （OTA）， fumonisins （FBs）， alternariol （AOH）， alternariol monomethyl ether （AME）， tentoxin （TEN） and tenuazonic acid （TeA） in wheat and wheat-based products via Meta-analysis.Methods The databases include PubMed， Web of Science， CNKI and WANFANG database.Results A total of 69 eligible studies were included in this study， related to 22，308 samples. The global pooled prevalence of mycotoxins in wheat and wheat-based products was 58% （95%CI： 51%-66%）， which mainly were TeA （99%）， TEN （88%）， DON （85%）， AFs （57%）， ZEN （42%）， T2 （39%）， AOH （30%）， AME （29%）， NIV （28%）， HT2 （25%）， OTA （21%） and FBs （16%）. The global pooled concentration of mycotoxins in wheat and wheat-based products was 32.80 μg/kg （95%CI： 24.96-43.10 μg/kg）. DON showed the highest concentration （317.53 μg/kg）， followed by TeA （117.37 μg/kg）， FBs （45.09 μg/kg）. The co-occurrence rate of DON-ZEN was 11.0%, 14.0% and 26.7%, TeA-TEN was 16.2%, TeA-TEN-AME was 14.3% and TeA-TEN-AOH-AME was 19.5%, respectively.Conclusion Wheat and wheat-based products showed different characteristics of mycotoxin contamination in different countries or regions, and the co-occurrence rate of more than one mycotoxin in wheat and wheat-based products was high, which should be paid attention to in the combined exposure assessment.