Objective To analyze the epidemiological characteristics of mushroom poisoning events in Changsha to provide reference to map out intervention strategies.Methods The epidemiological characteristics of mushroom poisoning events in Changsha reported through “Foodborne Disease Event Reporting System” from 2016 to 2020 was described.Results A total of 203 mushroom poisoning events were included with 618 poisoning cases and 15 deaths in Changsha from 2016 to 2020. The mushroom poisoning events mainly occurred during June to Sepetember， in rural areas and home sittings. The high-incidence areas were Ningxiang City， Changsha County and Liuyang City. From 2016 to 2020， the number of mushroom poisoning events that occurred in the central city area of Changsha （Furong District， Kaifu District， Yuelu District， Tianxin District and Yvhua District） was lower than that occurred in the surrounding counties and cities of Changsha （Wangcheng District， Changsha County， Ningxiang City and Liuyang City）（χ²=17.117， P=0.002）. In 2017， the number of mushroom poisoning events in Changsha was the biggest， and the number in other years was similar， and the number of deaths showed a decreasing trend.Conclusion The mushroom poisoning events in Changsha has seasonal and regional high-incidence characteristics. The measures of publicity intervention for residents over 50 years old in rural areas of surrounding counties and cities should be improved to reduce the occurrence of mushroom poisoning events.