Objective The purpose of this study is to compare genotoxicity methods between OECD test guidelines and China food safety standards（GB15193）．Methods Main parameters of related genotoxicity methods in OECD Testing Guidelines and GB 15193 standards were compared and analyzed．Results The methodology system of genotoxicity tests was similar between OECD and GB15193. However， there were some different recommendations in some parameters including cells/animal selection， treatment concentrations/dose selection and evaluation of results， etc.Conclusion As a set of internationally recognized standards， OECD test guidelines can be beneficial to the improvement of GB15193 standards on genotoxicity.