Objective To investigate the residues of quinolones，tetracyclines and metronidazole in chicken and egg samples in Hubei from 2016 to 2019.Methods A total of 373 chicken and 365 egg samples collected from 15 cities in Hubei Province were detected by ultra performance liquid chromatography tandem mass spectrometry.Result Antibiotics residues were detected in 65 chicken and 50 egg samples monitored from 2016 to 2019. The annual antibiotics detection rates in chicken were 9.76%（8/82）， 16.67%（16/96）， 38.14%（37/97）and 4.08%（4/98）， respectively. In egg samples， the detection rates were 15.00%（12/80），8.24%（7/85），24. 00%（24/100），7.14%（7/98）， respectively. There were significant differences in the annual detection rates of antibiotics in chicken and egg samples（P<0.001，P=0.002）. There was no statistical difference in the detection rate of antibiotics at different sampling sites （χ²=0.053， P=0.819）. Doxycycline， enrofloxacin，ciprofloxacin，ofloxacin，norflocaxin and other banned antibiotics were found in eggs，in addition， metronidazole were both detected in chicken and egg samples .Conclusion This study indicated that the exposure of quinolones in chicken were in the safe range，but some banned antibiotics in chickens and eggs might lead health risks to people.