Objective A method was developed for the simultaneous determination of nine novel brominated fire retardants （NBFRs） in milk by atmospheric pressure gas chromatography-tandem mass spectrometry （APGC-MS/MS）， and the extraction solvent and clean-up method were optimized.Methods The freeze-dried milk samples were extracted by hexane/dichloromethane （1∶1， V/V）， cleaned up by GPC and further degreased by sulfuric acid， and then analyzed by Multi-selected reaction monitoring（MRM） mode.Results The result showed that there were good linear relationships for the target compounds in a certain concentration range， with their correlation coefficients （R²） no less than 0.99. The limits of detection and the limits of quantification （LOQs） were 0.000 2-0.098 4 μg/L （fw） and 0.000 5-0.295 2 μg/L （fw）， respectively. The spiked recoveries were 73.94%-116.98% with RSD not more than 19.30% using blank milk. The method has been successfully applied to 22 milk samples. Among them， PBT， PBEB， EH-TBB， BTBPE and DBDPE were the major contaminants with the detection rates of 86.36%， 100.00%， 54.55%， 50.00% and 54.55%， respectively. The concentrations were 0.001-0.20 μg/L （fw）， < LOQ-0.06 μg/L （fw）， < LOQ-0.11 μg/L （fw） and < LOQ-0.85 μg/L （fw）， respectively.Conclusion The method was sensitive， precise and accurate， and can be used for the simultaneous determination of 9 NBFRs in milk.