Objective To study the problems and reasons of quality and safety management of imported aquatic products in Shanghai under regular epidemic prevention and control, and to provide countermeasures for the optimization of quality and safety management of imported aquatic products in Shanghai. Methods Combined with the analysis of literature and second-hand data, the in-depth interviews with government departments and enterprises were taken in this paper. Results It was found that Shanghai municipal government departments had adopted the following measures in port inspection, transportation, distribution and processing, and retail consumption, focusing on the quality and safety management of imported aquatic products, such as split-flow stacking, "three points and one warehouse" closed-loop management, traceability of imported cold-chain food enterprises, and so on. However, there were still some problems, such as the high uncertainty of quality and safety of imported aquatic products, the speed of customs clearance could not meet the expectations of enterprises, the pressure of centralized supervision, the coexistence of repeated and missing requirements of "three certificates" , and the lack of consumer confidence. Conclusion On this basis, it is suggested to improve the quality and safety management of imported aquatic products in Shanghai by improving the efficiency of obtaining overseas epidemic risk information, optimizing the customs clearance process of goods, building special warehouses for enterprises, strengthening the research and development of disinfection technology and refining disinfection requirements, supporting aquatic products trading enterprises through multiple channels, and guiding public opinion to boost consumer confidence.