Objective To investigate and analyze the epidemiological characteristics of a wild mushroom poisoning event in Qinhuangdao City, identify the species of poisonous mushroom, summarize the experience of investigation and treatment, and put forward prevention and control measures, and provide reference for the treatment and prevention of wild mushroom poisoning patients. Methods The poisoning events were analyzed by using the method of epidemiological investigation, morphological identification and mushroom toxin detection. Results Four villagers in Qinhuangdao city had nausea, abdominal pain, diarrhea, sweating and shivering after eating wild mushrooms. Patients were treated with vomiting, gastric lavage, atropine and other symptomatic treatment in the hospital, and the prognosis of the patients was good. After morphological identification and toxin detection, it was determined that food poisoning caused by mushroom of inocybe. Conclusion This is the first reported poisoning event caused by mushroom of inocybe in Hebei Province. The reason of poisoning was misguided by the Internet and poor self-awareness of food safety. Therefore, publicity and education should be strengthened, enhancing the awareness to prevent the poisoning of wild mushroom.