Objective In order to discover the pulsed field gel electrophoresis (PFGE) serotypes and drug resistance of Salmonella agona (S. agona) in Sichuan Province during 2008 to 2018, so as to understand the contamination status of S. agona and provide reference data for outbreak warning, traceability investigation and antibiotic use strategy. Methods A total of 61 S. agona strains after the serological and biochemical identification were analyzed by PFGE and tested for minimal inhibitory concentration of 14 antibiotics. Results The isolates of S. agona were divided into 41 PFGE types, some strains isolated from clinical cases in different years and regions had the same PFGE type, one pork isolate had the same PFGE type as some clinical isolates. The antibiotic resistance test indicated 28 of the isolates were sensitive to 14 kinds of antibiotics, the other 33 strains showed different degrees of drug resistance, nearly half of the strains were insensitive to tetracycline; and there were 16 multidrug-resistant strains. All of the isolates were sensitive to imipenem. Conclusion The PFGE types of S. agona isolated in Sichuan from 2008 to 2018 showed diversity, and they were sporadic prevalent in Sichuan Province. The drug resistance was serious with an increasing trend.