Objective To study the similarities and differences of food safety indicators in the National Food Safety Standard and international standards, and to provide a reference for the development and management of canned food industry. To study the similarities and differences of food safety indicators in the National Food Safety Standard and international standards, and to provide a reference for the development and management of canning industry. Methods Safety indicators in the relevant standards and regulations of canned food by China, Codex Alimentarius Commission (CAC), European Union (EU) and the United States were compared from the aspects of histamine, pollutant, biotoxin, food additive and others. Relevant standards and regulations on the safety indicators of canned food by China, Codex Alimentarius Commission (CAC), European Union (EU) and the United States were collected and compared from the aspects of histamine, pollutant, biotoxin, food additive and other indicators.Results In terms of the limit of histamine, there were no provisions in the relevant laws and regulations of the United States, while China and CAC had set their limits in canned fish. In terms of the limits of pollutants, China's provisions were relatively comprehensive in all kinds of canned food and food contact materials than those in other countries. In terms of the limit of biotoxin, only China and the United States had clear requirements. In terms of the types of canned food, the types, functions and the requirements of additives, China, CAC and EU were similar, while the regulations of the United States were totally different. In terms of the safety limit requirements of histamine, there are no provisions in the relevant laws and regulations of the United States, while China and CAC have set their limits in the canned fish; in terms of the safety limit requirements of pollutants, China's provisions are relatively complete, and the pollutant limit requirements in all kinds of canned food and food contact materials are more comprehensive than those in other countries; in terms of the safety limit requirements of biotoxin, only China and the United States have clear requirements; In terms of the types of canned food, the types of additives that can be used, the functions that can be used and the requirements for use, China, CAC and EU are similar, while the regulations of the United States are totally different from those of the other three countries or organizations. Conclusion Process control is the essence of canned foods safety, which provides thoughts on the future standard setting and revision in China, and is also worth learning for the canned food manufacturing industry. It is necessary to strengthen the prevention and control of pollutants in canned food, control the pollutant in raw materials and migration from processing equipment and food contact materials, and research on the safety of process parameters, and further establish and improve food safety risk control and traceability system. Process control is the essence of canned foods safety control, which provides thoughts on the future standard setting and revision work in the food field in China, and is also worth learning for the canned food manufacturing industry in China. It is necessary to strengthen the prevention and control of pollutants in canned food, strengthen the procurement and acceptance of raw and auxiliary materials, prevention, and control of pollutant migration in production and processing equipment and food contact materials, and research on the safety of process parameters, and further establish and improve food safety risk control and traceability system.