Objective To understand the epidemic characteristic and economic burden of acute gastroenteritis among community population, and to provide more accurate basic data for evaluating the prevalence of foodborne disease and single disease burden. To understand the epidemic characteristic and economic burden of acute gastroenteritis among community population, and to provide more accurate basic data for evaluating the prevalence of foodborne disease and single disease burden. Methods Using the stratified multi-stage random sampling method, 20 neighborhood committees (administrative villages) in 10 residential districts (township) of Xiuzhou and Tongxiang County were selected as the survey points. The indoor questionnaire investigation was carried out from July 2018 to June 2019 to survey the incidence rate and economic burden of acute gastroenteritis. Using the stratified multi-stage random sampling method, 20 neighborhood committees (administrative villages) in 10 residential districts (township) of Xiuzhou and Tongxiang County were selected as the survey points. The indoor questionnaire investigation was carried out from July 2018 to June 2019 to survey the incidence rate and economic burden of acute gastroenteritis.Results A total of 2 400 cases were surveyed, 62 person times of acute gastroenteritis were found, and monthly incidence rate was 2.58%(95%CI:1.95%-3.22%). There was no statistical significance in incidence rate between urban and rural areas, and no statistical significance in different gender and ages. Modified by the gender and age composition, monthly incidence rate was 2.92%(95%CI: 2.25%-3.60%), estimated annual incidence rate was 0.38 times(95%CI:0.36~0.40) preson-year. The high incidence season was from July to September. Of all the cases identified, 12.77% reported seeking medical service, and 72.34% of the cases were related with the contaminated food. 62.50% of the cases under 29 years old, 83.33% of the preschool children, and cases of students and clerks suffered from diseases after eating purchased food. The average economic burden of cases was 399.62 Yuan/per time, including 294.61 Yuan of average direct medical cost, 39.83 Yuan of average direct non-medical cost and 65.18 Yuan of indirect cost. The total estimated economic burden of acute gastroenteritis in Jiaxing was 719 million, including 520 million from foodborne disease. A total of 2 400 cases were surveyed, 62 person times of acute gastroenteritis were found, and monthly incidence rate was 2.58%(95%CI:1.95%-3.22%). There was no statistical significance in incidence rate between urban and rural areas, and no statistical significance in different gender and ages. Modified by the gender and age composition, monthly incidence rate was 2.92%(95%CI: 2.25%-3.60%), estimated annual incidence rate was 0.38 times(95%CI:0.36-0.40)preson-year. The high incidence season was from July to September. Of all the cases identified, 12.77% reported seeking medical service, and 72.34% of the cases were related with the contaminated food. 62.50% of the cases under 29 years old, 83.33% of the preschool children, and cases of students and clerks, suffered from diseases after eating purchased food. The average economic burden of cases was 399.62 Yuan/per time, including 294.61 Yuan of average direct medical cost per time, 39.83 Yuan of average direct non-medical cost per time and 65.18 Yuan of indirect cost per time. The total estimated economic burden of acute gastroenteritis in Jiaxing was 719 million, including 520 million total economic burden of foodborne disease. Conclusion The disease burden of acute gastroenteritis in Jiaxing was relatively heavy. It is suggested to strengthen health education for key population, guide the establishment of health dietary behavior, and continue to carry out relative surveillance. The disease burden of acute gastroenteritis in Jiaxing is relatively heavy. It is suggested to strengthen health education for key population, guide the establishment of health dietary behavior, and continue to carry out relative surveillance.