Objective To study the drug resistance characteristics of Salmonella isolated from diarrheal patients in Shunyi, Beijing. Methods Collected stool samples of diarrheal patients in Shunyi, Beijing 2013-2018. Isolation, bacterial identification and serotyping were tested for Salmonella strains. To analyze Drug resistance rate, non-drug sensitivity rate, multi-drug resistance rate and drug resistance profile of Salmonella strains to 26 antibacterial drugs were analyzed by broth dilution test method. Results The prevalence of Salmonella in diarrhea patients was 5.44% (113/2 076). Twenty-six serotypes were identified in 114 Salmonella strains, and the dominate serotypes were Salmonella enteritidis and Salmonella typhimurium with the composition ratio value of 32.46% (37/114) and 27.19% (31/114), respectively. The multi-drug resistance rates of Salmonella spp., S. enteritidis and S.typhimurium were 44.74% (51/114), 67.57% (25/37) and 45.16% (14/31), respectively. Salmonella spp., S.enteritidis and S.typhimurium were distributed 62,29 and 20 kinds of drug resistance profiles, respectively. Conclusion The drug resistance of Salmonella isolated from diarrhea patients was serious, and the distribution of drug resistance profile showed large diversity. It is necessary to continued high-quality pathogenic surveillance of Salmonella, so as to provide basis for scientific prevention and treatment of Salmonella infection.