Objective To understand the epidemic trend and characteristics of foodborne diseases caused by specific pathogens in Pudong New Area of Shanghai,so as to provide scientific evidence for disease prevention and control. Methods From 2015 to 2018, the infectious cases with diarrhea as the main complaint were collected from the sentinel hospital of foodborne disease active monitoring in Pudong New Area of Shanghai. Stool or anal swab samples were collected and tested for Vibrio parahaemolyticus, Salmonella, Shigella, diarrheogenic Escherichia coli, Campylobacter jejuni and Norovirus. At the same time, the profiles were collected and analyzed. Results In 2015-2018,2 871 stool or anal swab samples of diarrhea cases were monitored and collected. The positive rate of pathogens was 23.55%(676/2 871), including Norovirus 20.04%(97/484), diarrheogenic Escherichia coli 11.84%(340/2 871), Campylobacter jejuni 7.21%(68/943), Vibrio parahaemolyticus 4.01%(115/2 871), Salmonella 3.27%(94/2 871)and Shigella 0.28%(8/2 871).The positive rate was higher in the third quarter, showing a significant peak in summer and autumn. Suspicious food was mainly mixed food (41.12%,278/676), followed by aquatic animals and their products (22.19%,150/676) and meat and meat products (10.95%,74/676). Conclusion Norovirus and diarrheogenic Escherichia coli were the main pathogens of diarrhea cases in Pudong New Area of Shanghai. We should further improve the foodborne disease active monitoring system, carry out detailed epidemiological case investigation for specific pathogen positive cases, and provide technical support for effective prevention and control.