(1.National Health Commission of Key Laboratory of Food Safety Risk Assessment and Chinese Academy of Medical Science Research Unit No.2019RU014, China National Center for Food Safety Risk Assessment, Beijing 100022, China;2.Key Laboratory of Microbial Molecular Biology of Hunan Province, Hunan Provincial Center for Disease Control and Prevention,Hunan Changsha 410005, China;3.School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;4.China Animal Health and Epidemiology Center, Shandong Qingdao 266032, China)