Objective Summarize and analyze the common issues on new food additive applications, and make suggestions on both processes of submission and evaluation of applications for new food additives, and facilitate scientific, reasonable and standardized evaluation. Methods Use the “health administrative authorization management system” to obtain the statistics of new food additives applied in the year of 2010-2019, analyze the common problems, and put forward suggestions from technical aspects for new food additives. Results By analyzing final decisions of 769 new food additives applied in 2010-2019, common problems in both reception and safety evaluation stage were pointed out. On this basis, suggestions were put forward to further improve dossier requirements and safety data requirements from the management perspective. Conclusion The existing new food additive regulations and requirements can basically meet the needs of the safety evaluation. It is suggested to further refine the application requirements, formulate the application guidelines, and reinforce the safety evaluation requirements of new food additives.