People in the real world are exposed to multiple chemicals via multiple routes and co-exposure to multiple agents may induce joint effects, which draws extensive attention from the international community. Regulations of many countries oblige risk assessors to conduct cumulative risk assessments based on their own guidelines, findings of which provide the basis for scientific decision-making. By analyzing the method and frameworks of international risk assessment models of multiple chemicals, this paper explores the establishment of a risk assessment framework of multiple chemicals combined exposure to in food in China.