Objective To understand the contamination status and trend of foodborne pathogens in infant food in Guangxi Zhuang Autonomous Region, and provide reference to prevent and control the foodborne disease effectively. Methods Collecting infant food from 14 cities of Guangxi Zhuang Autonomous Region in 2011-2016. Four kinds of pathogenic bacteria were tested according to the food safety standard microbiological test(GB 4789) and the national food pollution and hazardous factors risk monitoring manual(2014). Results A total of 7 956 samples were detected. The positive rate of supplementary cereal food for infants and young children was 6.1% (249/4 084), and that of infant formula was 4.7% (183/3 872). The positive rates of Enterobacter sakazakii, Bacillus cereus(not in 2011 and 2015) and Staphylococcus aureus were 2.7%-5.6%, 2.3%-8.5% and 0.0%-0.4% respectively in supplementary cereal food for infants and young children. In the infant formula, the positive rate of Enterobacter sakazakii was from 0.2% to 1.8%. Bacillus cereus was 10.2%-12.4%(not in 2011 and 2015), and Staphylococcus aureus was 0.0%-0.3%. Salmonella was detected in one sample, and the origin was Inner Mongolia Autonomous Region. The positive rate of supplementary cereal food for infants and young children was 6.1%(248/4 077)in domestic products, while there was 1 positive in 7 foreign samples. In formula food, the positive rate was 4.7%(177/3 758)in domestic products and 5.3%(6/114)in imported products. Conclusion The contamination of Enterobacter sakazakii and Bacillus cereus in infant food sold in Guangxi Zhuang Autonomous Region posed a threat to infants. Therefore, it was necessary to strengthen the health supervision of domestic production enterprises.