RISK21:risk analyzing tool on dietary exposure of phthalic acid esters
Author:
Affiliation:

(National Health Commission Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100022, China)

Clc Number:

Fund Project:

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    Objective To analyze the risks of dietary exposure of diethylhexyl phthalate (DEHP), dibutyl phthalate (DBP), diisononyl phthalate (DINP), butylbenzyl phthalate (BBP), diisobutyl phthalate (DIBP), dimethyl phthalate (DMP) and diethyl phthalate (DEP) to 2-6 years children in China using RISK21, so as to provide risk management strategy for phthalic acid esters (PAEs). Methods RISK PLOT module was used to analyze and rank risks, with toxicity as Y-axis and exposure as X-axis and margin of exposure (MOE) and uncertainty factor as parameters. Matrix calculation was conducted, risks level and rank of 7 kinds of PAEs to 2-6 years children were illustrated by visualized graphs. TTC PLOT module was used to analyze risks of DMP, DEP and DIBP, which were lacking of toxicity data. Results RISK PLOT showed that the risks of 7 kinds of PAEs for general population located in the green area, which demonstrated that they had low risk to 2-6 years children, and the risks of high food consumption population ranked in descending order were DBP, DIBP, DEHP, DMP, DEP, DINP and BBP. TTC PLOT showed that the risks of DMP, DEP and DIBP were lower than the corresponding threshold of toxicological concern (TTC) that demonstrated low risks. Conclusion RISK21 framework and tools could be a very useful tool for risk assessment and further risk management, and low risks of dietary exposure of 7 kinds of PAEs to 2-6 years children in China by RISK21 analyzing.

    Reference
    Related
    Cited by
Get Citation

BAO Huihui, MAO Weifeng, SONG Yan, LIU Zhaoping, SUI Haixia, ZHANG Lei. RISK21:risk analyzing tool on dietary exposure of phthalic acid esters[J].中国食品卫生杂志,2020,32(2):190-195.

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:February 19,2020
  • Revised:
  • Adopted:
  • Online: May 01,2020
  • Published: