Over the last two decades, Salmonella 1,[5],12∶i∶- has been frequently detected in many countries or regions around the world, and nowadays it has become one of the major serotypes responsible for human infectious diarrhea. The etiology and genetic features of Salmonella 1,[5],12∶i∶- is quite similar with Salmonella Typhimurium(1,4,[5],12∶i∶1,2) but lacking the second phase flagellar antigen. It has evolved from Salmonella Typhimurium through multiple independent events involving different clonal groups or multiple clones. In this study, we reviews the epidemic characteristics including human infections, animal and animal-derived foods of Salmonella 1,[5],12∶i∶-, providing support for the prevention and control of infection and scientific researches.