Objective To establish a method for the simultaneous determination of fipronil and its metabolites in eggs by QuEChERS-gas chromatography-tandem mass spectrometry. Methods 3 ml water was added into egg samples (5.0 g), extracted with 10 ml acetonitrile, and purified in an EMR-Lipids tube. The analytes were performed on DB-5MS column (30 m×0.25 mm, 0.25 μm), detected under multiple reaction monitoring (MRM) mode, and was quantified by external standard method with matrix matching curve. Results The fipronil and its metabolites had a good linear in the range of 0-60 μg/L with the correlation coefficient r≥0.999 0. The detection limits (S/N=3) were 0.5-0.8 μg/kg, and the limits of quantification (S/N=10) were 1.7-2.7 μg/kg. The recoveries were 92.0%-115.5%, and the relative standard deviation (RSD) were 3.6%-6.8% (n=6). Conclusion The method has the characteristics of simple pretreatment, high sensitivity and high recoveries, and it is suitable for the accurate determination of fipronil and its metabolites in eggs.