The most rigorous standards, the strictest supervision, the harshest accountability and the gravest punishment (“4 Most”) highlighted by President Xi are the principles to improve national food safety control system in which the most rigorous standards is the first step. The precise content, regulated process and implementation comprise the rigorous standard system. Combined with the theme of “Remain true to our original aspiration and keep our mission firmly in mind” education activities, the procedure starts from strategic planning, initiation, elaboration, approval and review of standards which are the pillars to build a comprehensive China national food safety standard system. The article briefly introduces the background of the “4 Most” and the current food safety standard development progress, then further explains the meaning of the most rigorous standards with actions which need to be taken in the future in order to fulfill the target.