Objective This study aimed to get a better understanding of epidemiological characteristics of mushroom poisoning events in Anhui Province to provide reference to map out intervention strategies. Methods The descriptive analysis was conducted on the data of mushroom poisoning events and cases in Anhui Province reported through “Foodborne Disease Event Reporting System” and “Foodborne Disease Surveillance Reporting System” from 2016 to 2017. Results A total of 129 mushroom poisoning events were included with 223 poisoning cases and 2 deaths in Anhui Province from 2016 to 2017.The mushroom poisoning events mainly occurred during August to October, in the rural areas and home sittings, and were high in border region between Wanbei and Wanzhong, and Wannan mountain region. The most of patients were older than 40, and the common clinical findings were gastrointestinal symptoms, the correct rates of first visit were 69.23%(90/130). Conclusion Mushroom poisoning events in Anhui Province showed high risk season and area, effective intervention measures should be taken to key population and district in order to reduce mushroom poisoning events.