Objective To explore the regularity and features of the poisonous animal and plant poisoning incidences and provide the bases to build up the prevention and control measures. Methods The database for poisonous animal and plant poisoning in Yunnan from 2012 to 2017 was set up, and the times, places and poisoning factors were analyzed. Results There were 530 incidents,4 147 cases and 64 deaths.The incident peak was from October to December, accounted for 30.8%(163/530),37.4%(1 553/4 147) and 50.0%(32/64) of the reported incidents, cases and deaths for the whole year. The largest number of poisonous plant poisoning incidents happened in the Chuxiong City, Dali City and Yuxi City, accounted for 44.2%(212/480). The largest number of poisonous animal poisoning incidents happened in the Diqing City, Nujiang City and Baoshan City, accounted for 80.0%(40/50). The largest number of incidents, cases and deaths happened in the family scenario,accounted for 63.6%(337/530),40.3%(1 672/4 147) and 89.1%(57/64) respectively.Poisonous animal poisoning was mainly caused by pupa 7.9%(42/530), poisonous plant poisoning was mainly caused by aconite 30.2%(160/530), kidney bean 29.2%(155/530),castor bean 5.3%(28/530), honey 3.8%(20/530) and oil tree 3.6%(19/530). Conclusion The situation of poisoning caused by poisonous animal and plant was serious in Yunnan Province.The efficient emergency response system of outbreaks had to be improved to decrease the mortality rate of the incidence. Food safety inspection and education should be strengthened.