Objective To analyze the foodborne diseases caused by paralytic shellfish toxin poisoning outbreak causes and epidemiological characteristics, summarizes the survey disposal experience, to provide a basis to guide the prevention and control work. Methods The incident investigation and disposal process was reviewed, and the epidemiological characteristics and the prevention and control effect was analyzed and evaluated. Results This incident was caused by sea shellfish during red tide with 164 cases, the total number of people over 50 was 57.9%(95/164), the major clinical manifestations were breath limbs numb (100.0%,164/164), fatigue (75.0%,123/164)the shortest incubation period of the patient was 10 min, the maximum incubation period was 24 h, and the average latency was 3 h, the suspected pathogenic food was the shellfish, such as fresh food and oyster, and 8 out of 10 samples were detected paralytic shellfish poison. After comprehensive prevention and control measures, the incident was controlled. Conclusion Relevant departments should increase the publicity of red tide damage, expand the scope of red tide surveillance, timely release warning of hazards, and reduce the risk of shellfish poisoning.