Objective To establish a new method for determination of migration of hexavalent chromium in food contact materials. Methods After immersion in food simulants, ammonium chloride-ammonia solution was used as the eluent. The IonPacAS7 (4 mm×250 mm) anion analysis column was used for separation, and directly detection was performed by the ultraviolet (UV) detector at 350 nm wavelength. Results This method showed a good linear in the range of 0.001-0.5 mg/L, the linear equation was y=10.8554x+0.00472, r=0.999 9. The detection limit was 0.000 3 mg/L, the limit of quantification was 0.001 mg/L. The recovery rate was in the range of 88%-113%, and the relative standard deviation was in the range of 1.9%-9.0%(n=6). Conclusion This method had the characteristics of high sensitivity, good accuracy, low detection limit and easy operation. It was suitable for routine sample detection.