Rhabdomyolysis is a multiple pathological change syndrome that striates muscle cells and cell membrane channels are damaged by a series of factors.Haff disease is one kind of rhabdomyolysis due to eating cooked seafood within 24 h and serum creatine kinase (CK) level is markedly(fivefold or greater above normal levels) elevated, and CK muscle/brain (MB)fraction is less than 5%. At present, the experimental research reports of the disease is relatively scare and most of them were mainly based on case reports and epidemiological investigation. Now, the pathogenicity factor of such disease has not been found. Because of the disease has individual differences and some regional differences, this paper summarizes the existing case reports of haff disease that including the research progress related with crayfish eating in China. We hope this paper can provide some reference to the study of this disease.