Objective This study aimed to assess the disease burden of infectious diarrhea caused by Norovirus in Shanghai, and provide evidence for the government management decision and control measures of infectious diarrhea and foodborne disease. Methods The disease burden of infectious diarrhea was assess using the data from infectious diarrhea surveillance in Shanghai and the report of Norovirus infection outbreaks in Shanghai. The indexes included disability-adjusted life years (DALYs), morbidity, treatment rate and hospitalization rates. Results The total number of infectious diarrhea cases was 4.83 million, and 1.23 million cases were caused by Norovirus, 370 cases were hospitalized. The disease burden of infectious diarrhea caused by Norovirus in Shanghai in 2014 was 2 938.98 DALYs, 0.12 DALYs per thousand. Conclusion The disease burden of infectious diarrhea caused by Norovirus in Shanghai was high, and the government should give more attention to prevention, control and management of infectious diarrhea caused by Norovirus.