To investigate the distribution and drug resistance of Campylobacter spp. from slaughters and markets in Shijiazhuang City.Methods Chicken samples including anal swab before slaughter, ketones smear, chicken and liver were collected. Campylobacter spp. were isolated and identified according to GB/T 4789.9-2014 and multiplex polymerase chain reaction(PCR)method. The antibiotics susceptibility testing was conducted by the method of Kirby-Bauer with 12 kinds of antibiotics of 6 categories. Results Totally 17 strains of Campylobacter spp. were detected from 439 samples and the detection rate was 3.9%(17/439). The resistance rates of Campylobacter jejuni to nalidixic acid, levofloxacin, ciprofloxacin and tetracycline were 85.7%(6/7).All Campylobacter jejuni isolates were susceptible to gentamicin, streptomycin, amikacin, azithromycin and florfenicol. Furthermore, the resistance rate of Campylobacter coli to azithromycin, doxycycline and florfenicol was less than 50.0%, while was up to 80.0% to ciprofloxacin, levofloxacin, nalidixic acid, gentamicin, amikacin, tetracycline, streptomycin and clindamycin. The multi-drug resistance rate of Campylobacter was 70.6%(12/17), which showed 11 resistance patterns. The drug resistance patterns from market isolates were more than those from the slaughterhouse, and both had different dominant drug resistance profiles. Conclusion There was a certain degree of Campylobacter contamination in the slaughter and market in Shijiazhuang. The multi-drug resistance of the isolates was serious.