Abstract:A analytical method was developed to determine bisphenol A(BPA), bisphenol F(BPF)and their chlorinated products in drinking water using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS).Methods Water samples were concentrated and purified with PLEXA solid-phase extraction catridges. The target analytes were separated on a BEH C18 column(2.1 mm×100 mm,1.7 μm)with gradient elution using acetonitrile and water, and identified under negative electrospray ionization. The matrix-matched standard calibration curves were used for the quantitative analysis. Results Good linearities were achieved for all analytes with correlation coefficient (r2) above 0.99. The quantitation limits of the method (LOQ) were in the ranges of 0.01-4.00 ng/L. The recoveries of the target analytes ranged from 78.8%-99.6%, with relative standard deviations (RSD) less than 12.2%. Forty drinking water samples were analyzed by the developed method, and the detection rate of BPA, BPF and 4Cl-BPA were 45.0%(18/40),40.0%(16/40)and 32.5%(13/40), the concentrations were 0.60-9.40 ng/L, <LOQ-106.20 ng/L and