The study aimed to explore the toxicity of tetrabromobisphenol A on peripubertal female rats.MethodsFemale rats aged 19-day were dietary exposed to tetrabromobisphenol A for 21days with four dosages (0,2, 6,8 mg/kg BW). There were 15 rats in each dosages group. During the experiment, vaginal opening and estrous cyclicity of rats were observed and recorded. Blood samples were collected for blood routine, biochemical indexes and hormone levels. Organ weighing and his-topathologic examinations were performed in end point. Results The weight gain, the age of vaginal opening and weight, estrous cyclicity and hormone levels of rats in all the treated groups were similar to those in the non-treated group with no statistically significant difference. Liver/body weight ratio of all the treated groups, thyroid/body weight ratio of the high dosage group and thyroid/brain ratio of the low and high dosage group were significantly decreased. Blood routine showed that platelet count and plateletcrit were significantly decreased in the middle dosage group. Clinical biochemical parameters showed that the total cholesterol and glucose were significantly decreased in the middle and the high dosage group. The level of high density lipoprotein was significantly decreased in all the treated groups. No pathological changes in ovaries, uterus, livers, kidneys and thyroids were observed under microscope.Conclusion Tetrabromobisphenol A etrabromobisprenol may effect on liver, thyroid and glucose metabolism on peripubertal female rats.