A method was developed for the determination of 23 pesticides residues in vegetables, including organophosphorus and pyrethroid pesticides.Methods The pesticides in samples were extracted with acetone/dichloromethane(1∶1, V/V) and cleaned up by automatic solid-phase extraction. The collected solution was analyzed by triple quadrupole gas chromatography-tandem mass spectrometry using multiple reaction monitoring (MRM) with internal standard. Results It showed good linearity with the correlation coefficients above 0.993 3 in the range of 0.05-0.80 mg/L, the recoveries were in the range of 75.0%-105.5%, and the limits of detection(LOD) were 0.02-0.70 mg/kg. The residues of cypermethrin and cyhalothrin exceeded the standard in a few vegetable samples.Conclusion The method could be applied to the routine analysis for various pesticides in vegetable samples.