To analyze the surveillance results of foodborne diseases from sentinel hospitals in Wenzhou in 2014, and explore the epidemiological trend and characteristics of foodborne diseases in order to provide scientific evidence for the local health administrative departments to formulate effective policies.Methods The stools or anal swabs from outpatient and inpatient cases with diarrhea were collected from sentinel hospitals in 2014 and specific pathogens including Salmonella, Shigella, Vibrio parahaemolyticus, Vibrio vulnificus, diarrheogenic E.coli and Norovirus were detected, and the relevant information of the cases were collected and analyzed. Results A total of 4 216 diarrhea patients were enrolled in Wenzhou in 2014, and 4 190 patients were sampled. 321 strains of pathogens were isolated in the lab, which included 218 strains of Vibrio parahaemolyticus, 48 strains of Norovirus, 44 strains of Salmonella, 6 strains of diarrheogenic E.coli, 3 strains of Shigella and 2 strains of Vibrio vulnificus. The surveillance data analysis showed that the peak of the incidence was during July and November, children under 5-years-old and population between 16-45 years-old were vulnerable population. Aquatic products took the largest proportion of the suspected food, followed by meat and poultry and their products.Conclusion Vibrio parahaemolyticus is the main foodborne pathogen in Wenzhou. It is necessary to strengthen the communication and cooperation mechanism between the health administrative department, CDC and the sentinel hospitals to improve the foodborne diseases monitoring network, and to enhance the surveillance capacity and health education of foodborne disease and carry out more effective preventive and control measures.