To establish a gas chromatography-mass spectrometry determination method for lubricant migration from food contact materials.Methods Using iooctane, 95% ethanol and MPPO as three kinds of lipids alternatives for food contact materials, the gas chromatography-mass spectrometry detection was conducted after trifluoroacetic anhydride derivation. Results The oleic acid amide and stearic acid amidea had good linear relationship within 0.2-20 mg/L, erucic acid amide and behenamide had good linear relationship within 1.0-30 mg/L. The limits of detection ranged from 0.026 to 0.14 mg/L. The recoveries were in the range of 76.2%-97.3% with the relative standard deviation of 1.2%-6.3%.Conclusion The method was simple, rapid and accurate, and suitable for the detection of lubricants migration from food contact materials in lipid food stimulants.