To establish a method for determination of 11 bactericides and fipronil residues in fruits by liquid chromatography tandem mass spectrometry.Methods The samples were extracted by acetonitrile and then homogenized. The supernatants were separated after centrifuge and nearly dried with rotary evaporation. After the solid phase extraction of amino cartridge, the eluent was dried-up by the rotary evaporation. The analytes were dissolved by the mobile phase and determined by liquid chromatography tandem mass spectrometry. The conditions of separation and mass spectrometry were optioned. Results The relative standard deviations of detection were 4.7%-9.4%, the spiked sample recoveries were 78.6%-107.4%. The limits of quantification and detection were 0.002-2.2 and 0.000 4-0.66 μg/kg.Conclusion The method is simple, accurate, sensitive and could meet the determination requirements of pesticide residues in foods.