To discuss the investigation, disposal and information release for a cross regional food poisoning event, and to provide references for similar events.Methods Analyzing the reasons and risks of a Ⅲ level cross regional food poisoning event, discussing the process of investigation and the operation of information release. Results The food poisoning event was caused by eating Salmonella enteritidis contaminated mousse cakes, and Salmonella enteritidis was brought into mousse cakes in production processes. Conclusion Secondary operations of mousse cake had food safety risks, and HACCP management should be strengthened. Investigation and information release of cross regional food poisoning event should be carried out objectively, quickly and publicly coordinated by higher administration.