To develop a method to determine the nitrofuran metabolites in foods of animal origin by ultra high performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) and investigate the nitrofuran contamination situation in foods of Shaanxi.Methods 737 samples were collected in Shaanxi Province according to the principle of representation, timeliness and randomness. The samples were determined by UPLC-MS/MS after derivated with 2-nitrobenzaldehyde and purified by solid-phase extraction. Results The nitrofuran metabolites were detected in 29 out of 737 samples,with apositive rate of 3.93%. The highest detection rate was 8.05%from chicken and the detection rate of AMOZ was the highest among all metabolites which was 2.04%. Conclusion Some foods of animal origin of Shaanxi Province was contaminated by nitrofurans. Supervision and inspection should be strengthened in food production to ensure food safety.