To elucidate the contamination situation of deoxynivalenol (DON) and its derivatives in cereal and cereal-based products collected from Hebei region, 31 infant cereal food supplement, 112 oat and oat-based products and 293 wheat flour were investigated.Methods The samples were detected by liquid chromatography tandem mass spectrometry referred to the method of monitoring manual of chemical contaminants and harmful factors in food. Results 29 infant cereal food supplement samples were detected DON and the detection rate was 93.5%, 10 oat and oat-based products were detected DON and the detection rate was 8.9%, 292 wheat flour samples were detected DON and the detection rate was 99.7%. The serious contamination samples of DON in infant food supplement and oat-based products were contained wheat flour.Conclusion DON contamination in wheat flour was common. The maximum contamination level was 878.4 μg/kg, but all samples were below the national standards. Because there was no limit for DON in infant food supplement , the contamination was worthy of attention.