Cumulative risk assessment of anti-androgenic phthalate acid esters of adult liquor drinkers in Chinese population
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(China National Center for Food Safety Risk Assessment,Beijing 100022,China)

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    Abstract:

    To assess combined dietary exposure and health risk of anti-androgenic phthalate acid esters(PAEs) , that is,DEHP,DBP and BBP among Chinese adult liquor drinkers, including general drinkers population, male and female adults aged 18-59 years old as well as elderly male and female aged 60 and above.Methods Food samples were collected during 2011-2013 and categorized into 24 food groups which covered major foods in China. Food consumption data were taken from China national nutrition and health survey performed in 2002. Mean concentrations of individual PAEs were combined with individual food consumption data to estimate dietary exposure of DEHP, DBP and BBP respectively. Then, hazard index approach was used to calculate the cumulative risk of anti-androgenic phthalate acid esters. Results It was found that mean and high consumption (P97.5) for the general adult liquor drinkers as well as 4 age-gender groups were well below the corresponding tolerable daily intake (TDI) of DEHP, DBP and BBP respectively. Further analys is showed that there were 18 individuals having intake higher than the TDI of DBP, accounting for 0.64 percentage of Chinese adult liquor drinkers. As for combined exposure for DEHP, DBP and BBP, mean and high consumption consumer hazard index (P97.5) for the general adult liquor drinkers as well as 4 age-gender groups were well below 1. Further analysis showed that there were 22 individuals having hazard index higher than 1, accounting for 0.79 percentage of Chinese adult liquor drinkers.Conclusion It suggested that cumulative risk to anti-androgenic PAEs (DEHP, DBP and BBP) among general Chinese adult liquor drinkers population is low and do not pose an imminent health concern. A greater health risk exists for 22 adult liquor drinkers for whom moderate alcohol consumption is advised.

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SUI Hai-xia, WANG Shan, YANG Da-jin, LIU Zhao-ping, ZHANG Lei. Cumulative risk assessment of anti-androgenic phthalate acid esters of adult liquor drinkers in Chinese population[J].中国食品卫生杂志,2015,27(4):451-455.

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  • Received:
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  • Online: August 31,2015
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