A method of determination of lead in high salty food by GFAAS was established, and the interference model, various matrix modifiers, temperature program and correction model were explored.Methods Lead in high salty food was measured by standard addition method with Pd(NO₃)₂-NH₄H₂PO₄ as mixed matrix modifier after four kinds of pretreatment methods including microwave digestion, wet digestion, high-pressure tank digestion and direct dilution were adopted. Results While the salinity was below 2.2%, the interference could be eliminated by standard addition method with Pd(NO₃)₂-NH₄H₂PO₄ at the wavelength of 283.3 nm. The linear range was 1.8-40 μg/L. When 0.5 g sample were diluted to 10 ml, the limit of quantification was 0.036 mg/kg.Conclusion This method could eliminate the interference of high salinity during lead determination by GFAAS and improve the accuracy and reliability. The study provided good technical reserves for the revision and integration of national standards were established.