Food safety is one of the essential issues of public health in the world. Especially under the impact of globalization, factors influencing food safety are becoming diversified and complicated.In China the increasing number of food safety related incidents has attracted the public attention, and the various reasons in our society make it extremely difficult to be solved. As a new interdisciplinary approach, One Health has been adopted by many countries to settle food safety issues in practice successfully. In this review,new factors arising worldwide which lead to food safety problems was summarized, the meaning of One Health and the development and the practical use of it in other countries was then focuses on, aiming at providing valuable reference to the solution of Chinese food safety issues.